Novel auristatin E‐based albumin‐binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.01.010
Abstract: ABSTRACT Auristatins are a class of highly cytotoxic tubulin‐disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials. In our continuing effort to develop acid‐sensitive albumin‐binding anticancer drugs exploiting circulating serum… read more here.
Keywords: sulf07; binding prodrugs; albumin binding; auristatin ... See more keywords
Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-982
Abstract: A common theme in treating cancer is the use of combination chemotherapy, where multiple drugs with different mechanisms of action are combined to elicit synergistic activity or overcome differential drug sensitivities. Antibody-drug conjugates (ADCs) have… read more here.
Keywords: auristatin; delivery; adcs; drug ... See more keywords