Cisplatin‐resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12066
Abstract: De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and activation of aurora kinase A (AURKA) and eukaryotic translation initiation factor 4E… read more here.
Keywords: gastric cancer; resistance; cddp; aurora kinase ... See more keywords
Potential Value of AURKA and CDK6 Amplification for the Response of Patients With Gastric Cancer to Neoadjuvant Chemotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23921
Abstract: Many patients respond poorly to neoadjuvant chemotherapy (NACT), negatively affecting the surgical success rate. Identifying effective biomarkers and understanding the potential resistance mechanisms are urgently needed. Data of 18 patients with advanced stomach cancer who… read more here.
Keywords: aurka; cancer; neoadjuvant chemotherapy; response ... See more keywords
Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.5c01271
Abstract: Aurora kinase A (AURKA) is an established oncogenic factor and therapeutic target in neuroblastoma due to its roles in mitosis and stability of the MYCN protein. We previously identified SK2188 as a highly potent, selective,… read more here.
Keywords: aurka; degradation; aurka targeting; second generation ... See more keywords
Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c01752
Abstract: As a critical mitotic regulator, Aurora kinase A (AURKA) is aberrantly activated in a wide range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of solid tumors. In this study,… read more here.
Keywords: aurka; jab; 2485 potent; inhibitor ... See more keywords
Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation
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DOI: 10.1038/s41388-022-02293-y
Abstract: SMAD4 loss-of-function mutations have been frequently observed in colorectal cancer (CRC) and are recognized as a drug target for therapeutic exploitation. In this study, we performed a synthetic lethal drug screening with SMAD4-isogenic CRC cells… read more here.
Keywords: crc cells; crc; smad4 crc; smad4 ... See more keywords
Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.10.030
Abstract: BACKGROUND & AIMS Activation of KRAS signaling and overexpression of the aurora kinase A (AURKA) are often detected in luminal gastrointestinal cancers. We investigated regulation of ribosomal protein S6 kinase B1 (RPS6KB1) by AURKA and… read more here.
Keywords: gastrointestinal cancer; proliferation survival; aurka; cancer ... See more keywords
AURKA activates FOXO3a to form a positive feedback loop in the proliferation and migration of keloid fibroblasts.
Sign Up to like & getrecommendations! Published in 2024 at "Advances in wound care"
DOI: 10.1089/wound.2024.0055
Abstract: OBJECTIVE Keloids are benign fibroproliferative disorders with invasive growth exceeding the wound boundary. Aurora kinase A (AURKA) is a serine/threonine kinase highly expressed in various tumors, facilitating tumor growth and invasion. Currently, the role of… read more here.
Keywords: aurka; migration keloid; keloid fibroblasts; proliferation migration ... See more keywords
Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.170272
Abstract: Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well… read more here.
Keywords: mitochondrial morphology; targeting sequence; aurora kinase; aurka ... See more keywords
CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0631
Abstract: Clinical studies have shown that subsets of cancer patients achieve a significant benefit from Aurora kinase inhibitors, suggesting an urgent need to identify biomarkers for predicting drug response. Chromodomain-helicase-DNA-binding protein 1 (CHD1) is involved in… read more here.
Keywords: aurora kinase; sensitivity; aurka; chd1 ... See more keywords
Abstract 5961: Inhibition of AURKA destabilizes glioblastoma primary cilia and sensitizes cells to tumor treating fields (TTFields) in vitro and ex vivo
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5961
Abstract: Tumor Treating Fields (TTFields) can prolong survival of patients with glioblastoma (GBM), but GBM cells still escape this therapy requiring an urgent need for new or adjunct treatments. Recently we reported that TTFields disrupt primary… read more here.
Keywords: aurka; treating fields; treatment; cilia ... See more keywords
Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6379
Abstract: Aurora A kinase (AURKA) is an oncogene frequently overexpressed in adult solid tumors, hematologic malignancies, and pediatric cancers. AURKA plays an important role in mitosis, and cancer cells sensitive to loss of AURKA include lines… read more here.
Keywords: aurka; cancer; aurka degraders; identification selective ... See more keywords