Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma
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DOI: 10.1021/acs.jmedchem.5c01271
Abstract: Aurora kinase A (AURKA) is an established oncogenic factor and therapeutic target in neuroblastoma due to its roles in mitosis and stability of the MYCN protein. We previously identified SK2188 as a highly potent, selective,… read more here.
Keywords: aurka; degradation; aurka targeting; second generation ... See more keywords