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   Articles with "aurora" as a keyword



Cadherin-2 mediates spatiotemporal control of actomyosin contractility during zippering and neural tube closure in a simple chordate

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recommendations! Published in 2017 at "Mechanisms of Development"

DOI: 10.1016/j.mod.2017.04.254

Abstract: morphogenesis coupled to cell proliferation. Coordination of cell shape changes and cell divisions requires spatially-biased remodelling of actomyosin cytoskeleton in response to intrinsic or extrinsic inputs. In Caenorhabditis elegans zygotes, transient flows of cortical actomyosin… read more here.

Keywords: cell; actomyosin; cadherin mediates; actomyosin contractility ... See more keywords

Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

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recommendations! Published in 2017 at "Cell Discovery"

DOI: 10.1038/celldisc.2016.49

Abstract: Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor… read more here.

Keywords: spindle; checkpoint; haspin; late phase ... See more keywords

Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation.

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recommendations! Published in 2023 at "Molecular biology of the cell"

DOI: 10.1091/mbc.e23-01-0014

Abstract: Proper chromosome segregation depends on establishment of bioriented kinetochore-microtubule attachments, which often requires multiple rounds of release and reattachment. Aurora B and C kinases phosphorylate kinetochore proteins to release tensionless attachments. Multiple pathways recruit Aurora… read more here.

Keywords: aurora; kinetochore; chromosome segregation; centromere kinetochore ... See more keywords

Genetic interaction mapping of Aurora protein kinases in mouse oocytes

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recommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2024.1455280

Abstract: The Aurora Kinases (AURKs) are a family of serine-threonine protein kinases critical for cell division. Somatic cells express only AURKA and AURKB. However, mammalian germ cells and some cancer cells express all three isoforms. A… read more here.

Keywords: protein kinases; genetic interaction; aurora; mouse oocytes ... See more keywords

OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22041936

Abstract: Aurora kinases are serine/threonine kinases required for cell proliferation and are overexpressed in many human cancers. Targeting Aurora kinases has been a therapeutic strategy in cancer treatment. Here, we attempted to identify a deubiquitinase (DUB)… read more here.

Keywords: deubiquitinase; kinase; otud6a aurora; aurora kinase ... See more keywords