Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2018.09.006
Abstract: OBJECTIVES Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and… read more here.
Keywords: aurora kinases; hnc cells; hpv; hpv positive ... See more keywords
Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01222
Abstract: Aurora kinases (Aurora A, B, and C) are a family of serine/threonine kinases that play critical roles during mitotic initiation and progression. Aurora A and B kinases are ubiquitously expressed, and their overexpression and/or amplification… read more here.
Keywords: aurora kinase; kinase inhibitors; kinase; quinones aurora ... See more keywords
Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15901
Abstract: Oesophageal cancer is one of the most frequent solid malignancies and the leading cause of cancer‐related death around the world. It is urgent to develop novel therapy strategies to improve patient outcomes. Acetylation modification of… read more here.
Keywords: aurora kinases; cellular senescence; cancer; oesophageal cancer ... See more keywords
Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01943-22
Abstract: We have demonstrated that aurora kinases play a role during HSV-1 lytic infection. Three aurora kinase inhibitors significantly impaired HSV-1 immediate-early gene expression. ABSTRACT We utilized a high-throughput cell-based assay to screen several chemical libraries… read more here.
Keywords: aurora kinase; kinase inhibitors; replication; expression ... See more keywords
Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0670
Abstract: Mitotic progression is regulated largely by reversible phosphorylation events that are mediated by mitotic kinases and phosphatases. Protein phosphatase 1 (PP1) has been shown to play a crucial role in regulation of mitotic entry, progression,… read more here.
Keywords: phosphatase nuclear; nuclear targeting; aurora kinases; mitotic progression ... See more keywords
Expression of aurora kinases: Predictor of tumor dissemination in uterine carcinosarcoma.
Sign Up to like & getrecommendations! Published in 2017 at "Histology and histopathology"
DOI: 10.14670/hh-11-834
Abstract: Uterine carcinosarcoma is a rare, aggressive, and biphasic tumor. It comprises carcinomatous and sarcomatous components, and mitosis-associated factors are thought to discriminate these two lesions. Aurora kinases are mitotic enzymes that are highly expressed in… read more here.
Keywords: aurora kinase; expression; uterine carcinosarcoma; aurora kinases ... See more keywords
Aurora kinases: Generators of spatial control during mitosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1139367
Abstract: Cell division events require regulatory systems to ensure that events happen in a distinct order. The classic view of temporal control of the cell cycle posits that cells order events by linking them to changes… read more here.
Keywords: spatial control; control; aurora kinases; generators spatial ... See more keywords