Properties of Calmodulin Binding to NaV1.2 IQ Motif and Its Autism-Associated Mutation R1902C.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03189-7
Abstract: Voltage-gated sodium channels (VGSCs) are fundamental to the initiation and propagation of action potentials in excitable cells. Ca2+/calmodulin (CaM) binds to VGSC type II (NaV1.2) isoleucine and glutamine (IQ) motif. An autism-associated mutation in NaV1.2… read more here.
Keywords: cam; motif; autism associated; nav1 motif ... See more keywords
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1
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DOI: 10.1016/j.neuron.2020.02.033
Abstract: Mutations in Shank3 are strongly associated with autism spectrum disorders and neural circuit changes in several brain areas, but the cellular mechanisms that underlie these defects are not understood. Homeostatic forms of plasticity allow central… read more here.
Keywords: associated shank3; autism; compensation; autism associated ... See more keywords
Autism is associated with reduced ability to interpret grasping actions of others
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DOI: 10.1038/s41598-017-12995-z
Abstract: We investigated the ability of children with ASD to discriminate a small cylinder from a large cube by observing a point-light movie of an actor grasping the object, either from an allocentric or egocentric viewpoint… read more here.
Keywords: reduced ability; autism associated; interpret grasping; associated reduced ... See more keywords