The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.041
Abstract: The superfamily of vertebrate ribonucleases, a large group of evolutionarily related proteins, continues to provide interesting structural and functional information. In particular, the crystal structure of SS-RNase-2 from Salmo salar (SS2), here presented, has revealed… read more here.
Keywords: ribonuclease; inhibition; structural features; salmo salar ... See more keywords
Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201744454
Abstract: The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto‐inhibition. However,… read more here.
Keywords: auto; itch; auto inhibition; nedd4 family ... See more keywords