Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad456
Abstract: Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies defined an optimal primer binding site (PBS) length for the pegRNA of ∼13 nucleotides depending… read more here.
Keywords: inhibitory interaction; pbs; auto inhibitory; prime editing ... See more keywords