Pharmacokinetics and tolerability of prefilled syringe and auto-injector presentations of MSB11456: results of a randomized, single-dose study in healthy adults
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DOI: 10.1080/1744666x.2023.2174970
Abstract: ABSTRACT Background Tocilizumab is a monoclonal immunoglobulin G interleukin-6 receptor antagonist. MSB11456 is a proposed tocilizumab biosimilar. Objective To determine the pharmacokinetic equivalence of a single subcutaneous injection of MSB11456, when delivered via autoinjector (AI)… read more here.
Keywords: auto injector; prefilled syringe; study; msb11456 ... See more keywords
Adrenaline auto-injector injuries: Practical considerations in emergency management in a tertiary hand surgery unit
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DOI: 10.1097/md.0000000000032977
Abstract: Adrenaline auto-injectors are the first line treatment for anaphylaxis in the community setting. Both anaphylaxis and auto-injector carriage are increasing in prevalence. Adrenaline auto-injector injuries are common and most often involve the hand or digits.… read more here.
Keywords: emergency; auto injector; auto; injector injuries ... See more keywords
Bioavailability and cardiovascular effects of adrenaline administered by Anapen 500 μg auto‐injector in healthy volunteers
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DOI: 10.1111/bcp.15545
Abstract: Anaphylaxis guidelines recommend intramuscular adrenaline, commonly 300 μg administered using an auto‐injector device. However, overweight/obese patients may require a higher adrenaline dose for adequate cardiovascular (CV) response. This study evaluated the pharmacokinetics (PK) and pharmacodynamic (PD)… read more here.
Keywords: bioavailability cardiovascular; injector healthy; auto injector; cardiovascular effects ... See more keywords