De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2017.10.003
Abstract: Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown to be essential for normal learning and synaptic plasticity in mice, but its requirement for human brain development has not yet been established.… read more here.
Keywords: intellectual disability; camk2b; camk2a camk2b; auto phosphorylation ... See more keywords
Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.04.001
Abstract: Dual-specificity tyrosine-regulated kinases (DYRKs) auto-phosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. The auto-phosphorylation occurs intramolecularly and is a one-off event. DYRK3 is selectively expressed… read more here.
Keywords: auto; crystal structure; auto phosphorylation; tyrosine ... See more keywords
Auto-phosphorylation Represses Protein Kinase R Activity
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DOI: 10.1038/srep44340
Abstract: The central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively… read more here.
Keywords: auto; kinase activity; kinase; auto phosphorylation ... See more keywords
Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation
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DOI: 10.1371/journal.pone.0248668
Abstract: Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions. Protein kinase D… read more here.
Keywords: nlrp3 inflammasome; pkd; auto phosphorylation; activation ... See more keywords