Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24369
Abstract: Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization-mediated loss of NMDARs is thought to be the major… read more here.
Keywords: nr1 autoantibody; nmda receptors; autoantibody; synaptic proteins ... See more keywords
Cross‐sectional analysis reveals autoantibody signatures associated with COVID‐19 severity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28538
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID‐19 patients may develop a broad spectrum… read more here.
Keywords: infection; covid severity; autoantibody; autoantibody signatures ... See more keywords
Autoantibody Profiling Using Human Autoantigen Protein Array and AlphaScreen.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8802-0_10
Abstract: Autoantibodies that recognize self-antigens are believed to have close relationship diseases such as autoimmune diseases, cancer, and lifestyle diseases. Analysis of autoantibodies is essential for investigating pathology mechanisms, diagnosis, and therapeutics of these diseases. We… read more here.
Keywords: profiling using; autoantibody; protein array; autoantibody profiling ... See more keywords
Array-Based Profiling of Proteins and Autoantibody Repertoires in CSF.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9706-0_19
Abstract: Protein profiling enabled through affinity proteomics represents a powerful strategy for analysis of complex samples such as human body fluids. Cerebrospinal fluid (CSF) is the proximal fluid of the central nervous system and is commonly… read more here.
Keywords: autoantibody; autoantibody repertoires; array based; proteins autoantibody ... See more keywords
Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes
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DOI: 10.1007/s00251-017-0999-1
Abstract: Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested the hypothesis… read more here.
Keywords: autoantibody; t1d; association; reactivity ... See more keywords
Genetics of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-022-00912-0
Abstract: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints and is generally characterized by persistent pain, tenderness, and destruction of joints. The vast majority of RA patients produce autoantibodies, and immune cell involvement… read more here.
Keywords: hla; risk; rheumatoid arthritis; autoantibody ... See more keywords
Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium
Sign Up to like & getrecommendations! Published in 2018 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-018-0555-0
Abstract: We report a case of non-AIDS (acquired immunodeficiency syndrome), non-CAPD (Continuous Ambulatory Peritoneal Dialysis), non-cirrhotic, Mycobacterium avium peritonitis, which is a rare form of mycobacterial infection. A 66-year-old Japanese man who had been treated previously… read more here.
Keywords: autoantibody; cell lymphoma; avium; mycobacterium avium ... See more keywords
Therapeutic Management of Immune-Mediated Necrotizing Myositis
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DOI: 10.1007/s40674-021-00174-1
Abstract: The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation leading to chronic muscle weakness. Immune-mediated necrotizing myopathy (IMNM) is a distinct subgroup of inflammatory myopathy typically characterized by… read more here.
Keywords: autoantibody; imnm; treatment; mediated necrotizing ... See more keywords
Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype.
Sign Up to like & getrecommendations! Published in 2018 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.01.006
Abstract: We studied the clinical correlations and epitopes of autoantibodies directed to a novel autoantigen, Bicaudal D (BICD2), in systemic sclerosis (SSc) and reviewed its relationship to centromere protein A (CENP-A). 451 SSc sera were tested… read more here.
Keywords: autoantibody; ssc; systemic sclerosis; anti bicd2 ... See more keywords
Circulating bullous pemphigoid 180 autoantibody can be detected in a wide spectrum of patients with other dermatologic conditions: A cross‐sectional study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2018.06.006
Abstract: Fig 1. ROC curve for bullous pemphigoid 180 (BP180) autoantibody diagnostic test. Serum BP180 autoantibody was measured in 173 dermatologic in-patients seen during March 2016-October 2017 by using the BP180 NC16A ELISA (MBL, Nagoya, Japan).… read more here.
Keywords: dermatologic conditions; autoantibody; bp180 autoantibody; bullous pemphigoid ... See more keywords
A novel case of TIF1 gamma autoantibody positive dermatomyositis associated with a non-functional pancreatic neuroendocrine tumor.
Sign Up to like & getrecommendations! Published in 2019 at "Dermatology online journal"
DOI: 10.1016/j.jaad.2019.06.068
Abstract: Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with a distinct cutaneous eruption. The association of DM with malignancy has been extensively described in the literature. Patients with DM that… read more here.
Keywords: autoantibody; positive dermatomyositis; dermatomyositis associated; autoantibody positive ... See more keywords