An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Autoimmunity"
DOI: 10.1016/j.jaut.2021.102644
Abstract: We aim to establish a comprehensive COVID-19 autoantigen atlas in order to understand autoimmune diseases caused by SARS-CoV-2 infection. Based on the unique affinity between dermatan sulfate and autoantigens, we identified 348 proteins from human… read more here.
Keywords: a549; infection; autoantigen; host ... See more keywords
Co‐delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.09.034
Abstract: ABSTRACT Current therapies for autoimmune diseases focus on treating the symptoms rather than the underlying disease cause. A major setback in improving current therapeutics for autoimmunity is the lack of antigen specificity. Successful antigen‐specific immunotherapy… read more here.
Keywords: autoimmune; delivery; autoantigen; autoimmune encephalomyelitis ... See more keywords
A mutagenesis study of autoantigen optimization for potential T1D vaccine design
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214430120
Abstract: Significance The exact autoimmune mechanism responsible for causing Type 1 diabetes (T1D) remains unknown, but is thought to be a result of autoimmune activation by some potent self-antigen. A recent work isolated a unique cell… read more here.
Keywords: mutagenesis study; t1d; autoantigen optimization; study autoantigen ... See more keywords
Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.883000
Abstract: Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management of T1D faces the lack of fully predictive biomarkers in its… read more here.
Keywords: antigen specific; type diabetes; autoantigen; preclinical models ... See more keywords
A Novel Tolerogenic Antibody Targeting Disulfide-Modified Autoantigen Effectively Prevents Type 1 Diabetes in NOD Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.877022
Abstract: Increasing evidence suggested that the islet amyloid polypeptide (IAPP) is an essential autoantigen in the pathogenesis of type 1 diabetes (T1D) in humans and non-obese diabetic (NOD) mice. A unique disulfide containing IAPP-derived peptide KS20… read more here.
Keywords: nod mice; disulfide modified; type diabetes; autoantigen ... See more keywords
Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.951281
Abstract: The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide with critical roles in the development of peripheral sensitization and pain. One of the CGRP family peptides, islet amyloid polypeptide (IAPP), is an important autoantigen… read more here.
Keywords: cd4 cells; cgrp; type diabetes; cgrp specific ... See more keywords
Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030732
Abstract: The thymus is widely recognized as an immunological niche where autoimmunity against the acetylcholine receptor (AChR) develops in myasthenia gravis (MG) patients, who mostly present thymic hyperplasia and thymoma. Thymoma-associated MG is frequently characterized by… read more here.
Keywords: muscle; expression; thymoma; myasthenia gravis ... See more keywords