Cascade autohydrolysis of Alzheimer's Aβ peptides
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc06668h
Abstract: Protein/peptide self-assembly into amyloid structures associates with major neurodegenerative disorders such as Alzheimer's disease (AD). Soluble assemblies (oligomers) of the Aβ peptide and their aggregates are perceived as neurotoxic species in AD. While screening for… read more here.
Keywords: autocleavage; autohydrolysis; alzheimer peptides; autohydrolysis alzheimer ... See more keywords
Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4125670
Abstract: Accurate chromosome segregation requires timely activation of separase, a protease that cleaves cohesin during the metaphase-to-anaphase transition. However, the mechanism that maintains the inactivity of separase prior to this event remains unclear. We provide evidence… read more here.
Keywords: separase autocleavage; autocleavage; separase; binding cyclin ... See more keywords