Ezrin mediates both HGF/Met autocrine and non‐autocrine signaling‐induced metastasis in melanoma
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DOI: 10.1002/ijc.31196
Abstract: Aberrant HGF/Met signaling promotes tumor migration, invasion, and metastasis through both autocrine and non‐autocrine mechanisms; however, the molecular downstream signaling mechanisms by which HGF/Met induces metastasis are incompletely understood. We here report that Ezrin expression… read more here.
Keywords: autocrine; non autocrine; hgf met; metastasis ... See more keywords
PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity
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DOI: 10.1038/s41593-018-0184-3
Abstract: The protein kinase C (PKC) enzymes have long been established as critical for synaptic plasticity. However, it is unknown whether Ca2+-dependent PKC isozymes are activated in dendritic spines during plasticity and, if so, how this… read more here.
Keywords: autocrine; ca2; synaptic plasticity; pkc ... See more keywords
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
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DOI: 10.1038/s41598-021-87292-x
Abstract: When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming… read more here.
Keywords: igf2 programmes; autocrine igf2; cell plasticity; autocrine ... See more keywords