Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity.
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DOI: 10.1158/0008-5472.can-16-2913
Abstract: The tumor-promoting potential of CCL5 has been proposed but remains poorly understood. We demonstrate here that an autocrine CCL5-CCR5 axis is a major regulator of immunosuppressive myeloid cells (IMC) of both monocytic and granulocytic lineages.… read more here.
Keywords: autocrine ccl5; ccl5; ccl5 ccr5; ccr5 ... See more keywords