Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
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DOI: 10.1016/j.peptides.2017.11.015
Abstract: HighlightsChronic GLP‐1R stimulation promotes &bgr;‐cell metabolic reprogramming.IGF‐1R and IR are important for &bgr;‐cell development, function and proliferation.GLP‐1 enhanced metabolic phenotype is independent of IR and IGF‐1R autocrine loops.Enhanced metabolism can contribute to GLP‐1 pro‐survival abilities.… read more here.
Keywords: glp; activation; receptor; autocrine loops ... See more keywords