Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110632
Abstract: Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether the IL-2 signals perceived by CD8 T cells come from autocrine or paracrine sources, the timing of IL-2 signaling and their… read more here.
Keywords: cd8 cell; cd8 cells; memory; cell ... See more keywords
Telomeres: beacons of autocrine and paracrine DNA damage during skin aging
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1728016
Abstract: ABSTRACT Cellular senescence is an irreversible cell cycle arrest, which can be triggered by a number of stressors, including telomere damage. Among many other phenotypic changes, senescence is accompanied by increased secretion of pro-inflammatory molecules,… read more here.
Keywords: senescence; skin aging; damage; damage skin ... See more keywords
Autocrine/Paracrine Slit–Robo Signaling Controls Optic Lobe Development in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.874362
Abstract: Cell segregation mechanisms play essential roles during the development of the central nervous system (CNS) to support its organization into distinct compartments. The Slit protein is a secreted signal, classically considered a paracrine repellent for… read more here.
Keywords: lobe; development; autocrine paracrine; robo ... See more keywords
GPCRs in Autocrine and Paracrine Regulations
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DOI: 10.3389/fendo.2019.00428
Abstract: G protein-coupled receptors (GPCRs) constitute the largest superfamily of integral membrane protein receptors. As signal detectors, the several 100 known GPCRs are responsible for sensing the plethora of endogenous ligands that are critical for the… read more here.
Keywords: paracrine regulations; paracrine; autocrine paracrine; cell ... See more keywords
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma
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DOI: 10.3390/ijms18010149
Abstract: Resistance to conventional chemotherapeutic agents, a typical feature of cholangiocarcinoma, prevents the efficacy of the therapeutic arsenal usually used to combat malignancy in humans. Mechanisms of chemoresistance by neoplastic cholangiocytes include evasion of drug-induced apoptosis… read more here.
Keywords: chemoresistance; promoting chemoresistance; mechanisms promoting; cholangiocarcinoma ... See more keywords