Anti‐Inflammatory Macrophage‐Derived Exosomes Modified With Self‐Antigen Peptides for Treatment of Experimental Autoimmune Encephalomyelitis
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DOI: 10.1002/advs.202415265
Abstract: Current treatments for autoimmune diseases often involve broad‐acting immunosuppressants, which carry risks such as infections and malignancies. This study investigates whether exosomes derived from anti‐inflammatory macrophages (AE) and decorated with myelin oligodendrocyte glycoprotein (MOG) peptide… read more here.
Keywords: autoimmune encephalomyelitis; treatment; antigen; autoimmune ... See more keywords
B cell modulation with anti-CD79bantibodies ameliorates experimental autoimmune encephalitis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149523
Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like multiple sclerosis, rheumatoid arthritis or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for multiple… read more here.
Keywords: autoimmune encephalitis; cell modulation; experimental autoimmune; cell ... See more keywords
Epilepsy and systemic autoimmune diseases: A bidirectional two‐sample Mendelian randomization study
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DOI: 10.1002/epi4.70102
Abstract: Epidemiological data indicates that individuals with epilepsy exhibit an elevated susceptibility to autoimmune disorders, and conversely, those with systemic autoimmune diseases (SAD) demonstrate a heightened predisposition to epilepsy. Although an increasing number of publications support… read more here.
Keywords: sample mendelian; bidirectional two; systemic autoimmune; autoimmune ... See more keywords
Defining the role of systemic autoimmune markers in adult epilepsy: A focus on autoimmune-associated epilepsy.
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DOI: 10.1002/epi4.70159
Abstract: Autoimmune mechanisms are a recognized cause of adult epilepsy, with immunotherapy offering etiology‐specific treatment. Autoimmune‐associated epilepsy is an emerging clinical entity, for which early diagnosis remains challenging and largely depends on neuronal antibody testing. This… read more here.
Keywords: defining role; adult epilepsy; autoimmune associated; autoimmune ... See more keywords
Ferritin loss in astrocytes reduces spinal cord oxidative stress and demyelination in the experimental autoimmune encephalomyelitis (EAE) model
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DOI: 10.1002/glia.24616
Abstract: Demyelinating diseases such as multiple sclerosis (MS) cause myelin degradation and oligodendrocyte death, resulting in the release of toxic iron and iron‐induced oxidative stress. Astrocytes have a large capacity for iron transport and storage, however… read more here.
Keywords: spinal cord; iron; stress; oxidative stress ... See more keywords
Targeting IL‐34 in inflammatory autoimmune diseases
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DOI: 10.1002/jcp.28946
Abstract: Interleukin‐34 (IL‐34) shares a common receptor with macrophage colony‐stimulating factor (M‐CSF), and can bind to CSF‐1R, induces lymphocytes differentiation, proliferation, and regulates the synthesis of inflammatory components. Recent findings reported aberrant expression of IL‐34 in… read more here.
Keywords: targeting inflammatory; autoimmune; autoimmune diseases; physiology ... See more keywords
Incidence of autoimmune diseases in patients with scabies: a nationwide population-based study in Taiwan
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DOI: 10.1007/s00296-017-3717-2
Abstract: Scabies is a commonly occurring infectious immune-mediated inflammatory skin disease. Immune-mediated inflammatory processes are also observed in autoimmune diseases. There have been very few previous studies; however, that have investigated the possible association between scabies… read more here.
Keywords: autoimmune; nationwide population; population based; autoimmune diseases ... See more keywords
Lung fibrosis in autoimmune diseases and hypersensitivity: how to separate these from idiopathic pulmonary fibrosis
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DOI: 10.1007/s00296-021-05002-2
Abstract: Lung involvement in autoimmune diseases (AID) is uncommon, but may precede other organ manifestations. A diagnostic problem is chronicity presenting with lung fibrosis. A new category of interstitial pneumonia with autoimmune features for patients with… read more here.
Keywords: autoimmune; fibrosis; etiology; aid ... See more keywords
Borrelia burgdorferi and autoimmune mechanisms: implications for mimicry, misdiagnosis, and mismanagement in Lyme disease and autoimmune disorders
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DOI: 10.1007/s00296-024-05580-x
Abstract: The genus Borrelia encompasses a diverse group of spirochetes transmitted primarily by ticks, with Borrelia burgdorferi causing Lyme disease, which is prevalent in North America and Europe. Borrelia’s structural adaptations and ability to persist in… read more here.
Keywords: burgdorferi autoimmune; borrelia burgdorferi; autoimmune; autoimmune mechanisms ... See more keywords
The impact of autoimmune comorbidities on multiple sclerosis progression: insights from a longitudinal single-center study
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DOI: 10.1007/s00415-025-13351-2
Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The presence of other conditions alongside MS imposes a substantial personal and socioeconomic burden. In particular, the impact of comorbid autoimmune… read more here.
Keywords: multiple sclerosis; aid; autoimmune; impact ... See more keywords
Biomarkers and Pathogenic Mechanisms in Autoimmunity
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DOI: 10.1007/s12026-016-8864-0
Abstract: The overall frequency of all autoimmune diseases in the general population is estimated at 5–8 %. More importantly, there has been an alarming increase in incidence for autoimmune diseases in recent decades. All ages are… read more here.
Keywords: autoimmune; mechanisms autoimmunity; autoimmune diseases; pathogenic mechanisms ... See more keywords