Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117636119
Abstract: Significance Autoimmune demyelination is driven by pathogenic T cells and inflammatory myeloid cells. How myeloid and T cells functionally interact and contribute to inflammatory demyelinating disease, such as multiple sclerosis, remains incompletely understood. This study… read more here.
Keywords: myeloid caspase; myeloid cells; production; autoimmune demyelination ... See more keywords
Ataxin‐1 controls the expression of specific noncoding RNAs in B cells upon autoimmune demyelination
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12622
Abstract: B cells play a key mechanistic role in the pathogenesis of multiple sclerosis (MS), a chronic neurological disease of the central nervous system with an autoimmune etiology. B cells contribute to disease initiation and progression… read more here.
Keywords: cell; disease; noncoding rnas; autoimmune demyelination ... See more keywords
B cell targeting therapies in MS patients during the SARS-CoV-2 pandemic - when immunosuppression meets infection?
Sign Up to like & getrecommendations! Published in 2020 at "Neurologia i neurochirurgia polska"
DOI: 10.5603/pjnns.a2020.0083
Abstract: INTRODUCTION Research into the mechanisms of autoimmune demyelination have highlighted B cells in this process. Therapies targeting this population were a recent addition to the multiple sclerosis (MS) drugs portfolio. The SARS-CoV-2 pandemic and the… read more here.
Keywords: cov pandemic; patients sars; autoimmune demyelination; cell ... See more keywords