BJ‐2266 ameliorates experimental autoimmune encephalomyelitis through down‐regulation of the JAK/STAT signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646860
Abstract: CD4+ T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro‐environmental factors present during T‐cell priming, direct differentiation of naïve CD4+ T cells into pro‐inflammatory Th1 and Th17 cells. From extensive screening… read more here.
Keywords: cd4 cells; jak stat; differentiation; autoimmune encephalomyelitis ... See more keywords
MicroRNA 182 promotes T helper 1 cell by repressing hypoxia induced factor 1 alpha in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948111
Abstract: MicroRNA 182 is important for the clonal expansion of CD4+ T cells (Th) following IL‐2 stimulation and is a potential therapeutic target for autoimmune diseases. In the present study, we investigated the role of microRNA… read more here.
Keywords: autoimmune encephalomyelitis; microrna 182; helper cell; cd4 ... See more keywords
The modulatory effects of luteolin on cyclic AMP/Ciliary neurotrophic factor signaling pathway in experimentally induced autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2099
Abstract: Multiple sclerosis (MS) is considered to be an autoimmune disorder of the central nervous system (CNS) manifested by chronic inflammation. Although its etiology is not completely understood, inflammation and apoptosis are known to be major… read more here.
Keywords: cyclic amp; eae group; group; effects luteolin ... See more keywords
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27792
Abstract: Multiple sclerosis (MS) is a highly disabling demyelinating disease, which mainly affects young adults and is difficult to cure. Activated microglia may be involved in the process of neuronal cell damage and release inflammatory cytokines… read more here.
Keywords: multiple sclerosis; autoimmune encephalomyelitis; experimental autoimmune;
Dose‐dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25007
Abstract: Female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive… read more here.
Keywords: dose dependent; experimental autoimmune; visual function; autoimmune encephalomyelitis ... See more keywords
Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_26
Abstract: The protocol in this chapter presents a method to actively induce experimental autoimmune encephalomyelitis (EAE), one of the most widely used animal models to study efficacy of potential drugs for treatment of multiple sclerosis. Multiple… read more here.
Keywords: autoimmune encephalomyelitis; experimental autoimmune; c57bl mice;
Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7862-5_17
Abstract: Experimental autoimmune encephalomyelitis (EAE) is one of the most popular animal models of multiple sclerosis (MS). There are a number of EAE models, being actively induced EAE in strains such as C57Bl/6 mice very robust… read more here.
Keywords: encephalomyelitis eae; eae; autoimmune encephalomyelitis; experimental autoimmune ... See more keywords
Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2019 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-019-01786-4
Abstract: Oligodendrocyte degeneration is a hallmark of multiple sclerosis pathology, and protecting oligodendrocytes and myelin is likely to be of clinical relevance. Traditionally, oligodendrocyte and myelin degeneration are viewed as a direct consequence of an inflammatory… read more here.
Keywords: cuprizone; intoxication; autoimmune encephalomyelitis; active experimental ... See more keywords
The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00555-w
Abstract: Inflammatory demyelination in the central nervous system (CNS) is a hallmark of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Besides MS disease-modifying therapy, targeting myelin sheath protection/regeneration is currently a hot… read more here.
Keywords: encephalomyelitis eae; potential bilobalide; autoimmune encephalomyelitis; therapeutic potential ... See more keywords
An Apparent Correlation Between Central Nervous System and Kidney’s Erythropoietin and TNF Alpha Expression at Peak Experimental Autoimmune Encephalomyelitis Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1092-4
Abstract: Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelination disease associated with inflammatory reactions and attenuation of antioxidant capacity. Several lines of evidence show that organs such as the liver and kidneys can share their antioxidant… read more here.
Keywords: tnf; epo; expression; autoimmune encephalomyelitis ... See more keywords
p75NTR and TROY: Uncharted Roles of Nogo Receptor Complex in Experimental Autoimmune Encephalomyelitis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0841-7
Abstract: Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), have been on the forefront of drug discovery for most of the myelin inhibitory molecules implicated in axonal regenerative process. Nogo-A along with its… read more here.
Keywords: p75ntr; nogo receptor; p75ntr troy; autoimmune encephalomyelitis ... See more keywords