Th17 cells and their cytokines serve as potential therapeutic target in experimental autoimmune neuritis
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1478
Abstract: Accumulating evidence has pointed that T helper 17 cells and their cytokines are pathogenic in Guillain–Barré syndrome (GBS). However, little is known concerning the IL‐17 expression change trend during the whole course of disease, and… read more here.
Keywords: experimental autoimmune; cells cytokines; th17 cells; autoimmune neuritis ... See more keywords
Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2965
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated disease that targets the myelin sheaths of the peripheral nerves. Fingolimod is a sphingosine 1 phosphate (S1P) receptor antagonist with a high affinity for S1P receptors through… read more here.
Keywords: autoimmune neuritis; chronic experimental; experimental autoimmune; ameliorates chronic ... See more keywords
P95. Immunmodulatory effects of intrathecal administration of triamcinolone in experimental autoimmune neuritis model in lewis rats
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.04.717
Abstract: Objective We studied the immunmodulatory effects of triamcinolone applied intrathecally in the animal model of experimental autoimmune neuritis (EAN) in Lewis rats. Background Therapeutic efficacy of intravenous corticosteroids in chronic autoimmune neuritis has been shown… read more here.
Keywords: model; lewis rats; triamcinolone; autoimmune neuritis ... See more keywords
Anti-inflammatory and immunomodulatory potential of human immunoglobulin applied intrathecally in Lewis rat experimental autoimmune neuritis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2017.05.008
Abstract: Intravenous human immunoglobulins dominate in the treatment of autoimmune neuropathies. We introduce intrathecal application as a new option for experimental autoimmune neuritis in Lewis rats. After immunisation with neuritogenic P2 peptide, we show a therapeutic… read more here.
Keywords: anti inflammatory; autoimmune; immunoglobulin; autoimmune neuritis ... See more keywords
Ultrastructural characterization of mitochondrial damage in experimental autoimmune neuritis
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DOI: 10.1016/j.jneuroim.2020.577218
Abstract: Data are sparse about mitochondrial damage in GBS and in its most frequently employed animal model, experimental autoimmune neuritis (EAN). We here characterized changes in mitochondrial content and morphology at different time points during EAN… read more here.
Keywords: mitochondrial damage; autoimmune neuritis; schwann cells; ultrastructural characterization ... See more keywords
Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages Through Blocking Notch Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00272
Abstract: The diterpenoid compound, Oridonin, extracted from the Chinese herb, Rabdosia rubescens, possesses multiple biological activities and properties. Oridonin exhibited efficient anti-inflammatory activity by inducing a switch in macrophage polarization to the anti-inflammatory phenotype through inhibition… read more here.
Keywords: anti inflammatory; inflammatory macrophages; autoimmune neuritis; notch pathway ... See more keywords