Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24235
Abstract: Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis… read more here.
Keywords: oxidation; eae; neuroinflammation; odc mitochondria ... See more keywords
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02187-x
Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brain barrier… read more here.
Keywords: blood brain; heme oxygenase; autoimmune neuroinflammation; brain barrier ... See more keywords
Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0595-2
Abstract: In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF) efficacy to moderate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular substrate of this dimorphism was… read more here.
Keywords: autoimmune neuroinflammation; sex; action; dimethyl fumarate ... See more keywords
Physical exercise therapy for autoimmune neuroinflammation: Application of knowledge from animal models to patient care.
Sign Up to like & getrecommendations! Published in 2022 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2022.103033
Abstract: Physical exercise (PE) impacts various autoimmune diseases. Accordingly, clinical trials demonstrated the safety of PE in multiple sclerosis (MS) patients and indicated beneficial outcomes. There is also an increasing body of research on the beneficial… read more here.
Keywords: neuroinflammation; therapy; physical exercise; animal models ... See more keywords
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.01.004
Abstract: Pathologic roles of innate immunity in neurologic disorders are well described, but their beneficial aspects are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely known to induce inflammation. Here, we report that Dectin-1… read more here.
Keywords: autoimmune neuroinflammation; myeloid cell; card9 independent; cell astrocyte ... See more keywords
MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00758
Abstract: Background Recent studies have revealed that multiple sclerosis (MS) lesions have distinct microRNA (miRNA) expression profiles. miR-181 family members show altered expression in MS tissues although their participation in MS pathogenesis remains uncertain. Herein, we… read more here.
Keywords: 181a mimic; mimic sequences; autoimmune neuroinflammation; mir 181a ... See more keywords