Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin.
Sign Up to like & getrecommendations! Published in 2017 at "Reproduction"
DOI: 10.1530/rep-17-0010
Abstract: Experimental autoimmune orchitis (EAO) is a rodent model of chronic testicular inflammation that mimics the pathology observed in some types of human infertility. In a previous study, testicular expression of the inflammatory/immunoregulatory cytokine, activin A,… read more here.
Keywords: levels activin; group; autoimmune orchitis; mice ... See more keywords
High Throughput scRNA-Seq Provides Insights Into Leydig Cell Senescence Induced by Experimental Autoimmune Orchitis: A Prominent Role of Interstitial Fibrosis and Complement Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.771373
Abstract: Leydig cells (Lc), located in the interstitial space of the testis between seminiferous tubules, produce 95% of testosterone in male individuals, which is pivotal for male sexual differentiation, spermatogenesis, and maintenance of the male secondary… read more here.
Keywords: experimental autoimmune; autoimmune orchitis; senescence; high throughput ... See more keywords
Impaired Spermatogenesis in Infertile Patients with Orchitis and Experimental Autoimmune Orchitis in Rats
Sign Up to like & getrecommendations! Published in 2024 at "Biology"
DOI: 10.3390/biology13040278
Abstract: Simple Summary In the testis of infertile patients, we have demonstrated a high prevalence of immune cells (orchitis); their presence together with high FSH levels are associated with alterations in the behavior of nurturing Sertoli… read more here.
Keywords: orchitis; infertile patients; autoimmune orchitis; experimental autoimmune ... See more keywords