Proteome Dynamics in Biobanked Horse Peripheral Blood Derived Lymphocytes (PBL) with Induced Autoimmune Uveitis
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201700013
Abstract: Equine recurrent uveitis is the only spontaneous model for recurrent autoimmune uveitis in humans, where T cells target retinal proteins. Differences between normal and autoaggressive lymphocytes were identified in this study by analyzing peripheral blood… read more here.
Keywords: lymphocytes pbl; peripheral blood; autoimmune uveitis; derived lymphocytes ... See more keywords
Clinical and Functional Evaluation of Ocular Inflammatory Disease Using the Model of Experimental Autoimmune Uveitis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8938-6_15
Abstract: Non-infections uveitis in humans is an autoimmune disease of the retina and uvea that can be blinding if untreated. Its laboratory equivalent is experimental autoimmune uveitis (EAU) induced in susceptible rodents by immunization with retinal… read more here.
Keywords: histopathology; disease; evaluation; disease using ... See more keywords
Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113645
Abstract: Autoimmune uveitis (AU), a sight-threatening intraocular disorder, is still a challenge for ophthalmologists in clinic. Teriflunomide has been approved for multiple sclerosis (MS) in 2012 for its immunoregulatory function. However, the effect and mechanisms of… read more here.
Keywords: teriflunomide; dendritic cells; autoimmune uveitis; uveitis ... See more keywords
Stress Suppresses Systemic Th17/Treg Imbalance in Rats with Experimental Autoimmune Uveitis.
Sign Up to like & getrecommendations! Published in 2021 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2021.1970778
Abstract: PURPOSE To explore the effect of chronic unpredictable mild stress (CUMS) on the immune response involved in rats with experimental autoimmune uveitis (EAU). METHODS Lewis rats were randomly divided into control, EAU, CUMS, and EAU+CUMS… read more here.
Keywords: th17 treg; rats experimental; stress; autoimmune uveitis ... See more keywords
I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/6947482
Abstract: Regulatory dendritic cells (DCreg) have been reported to be a negative regulator in the immune response. These cells are widely distributed in the liver, spleen, and lung. However, the status and function of DCreg in… read more here.
Keywords: immune response; experimental autoimmune; autoimmune uveitis; eau ... See more keywords
Describing the Clinical and Laboratory Features and HLA-B Pattern of Adult-Onset Idiopathic Autoimmune Uveitis at a Tertiary Hospital in South India: A Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2022 at "The Scientific World Journal"
DOI: 10.1155/2022/5032881
Abstract: Introduction There is a scarcity of information available on clinical and laboratory features of adult-onset idiopathic autoimmune uveitis. Therefore, we conducted a single centre descriptive cross-sectional study. Patients and Methods. A chart review of all… read more here.
Keywords: rheumatology; autoimmune uveitis; retinal vasculitis; idiopathic autoimmune ... See more keywords
The Role of Gut Microbiome in Autoimmune Uveitis
Sign Up to like & getrecommendations! Published in 2020 at "Ophthalmic Research"
DOI: 10.1159/000510212
Abstract: The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and… read more here.
Keywords: role gut; autoimmune uveitis; gut microbiome;
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02080-8
Abstract: Background The integrin VLA-4 (α4β1) plays an important role in leukocyte trafficking. This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious posterior uveitis (experimental… read more here.
Keywords: gw559090; th17; blood; autoimmune uveitis ... See more keywords
Association between islet autoantibodies and the prevalence of autoimmune uveitis.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2020.11.08
Abstract: AIM To evaluate the predictive value of islet autoantibodies for the diagnosis of autoimmune uveitis (AU), as well as to characterize the association bet ween islet autoantibodies and AU. METHODS Totally 97 patients with AU… read more here.
Keywords: islet autoantibodies; islet antibodies; islet; autoimmune uveitis ... See more keywords
Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.601619
Abstract: As one of the leading causes of blindness worldwide, uveitis is an important disease. The exact pathogenesis of autoimmune uveitis is not entirely elucidated to date. Equine recurrent uveitis (ERU) represents the only spontaneous animal… read more here.
Keywords: metabolic phenotype; pathogenesis; eru cases; autoimmune uveitis ... See more keywords
Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.736261
Abstract: Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal pigment… read more here.
Keywords: expression; autoimmune uveitis; uveitis; experimental autoimmune ... See more keywords