PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-022-04173-w
Abstract: Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds… read more here.
Keywords: pstpip1 lyp; lyp phosphatase; autoinflammatory disorders; interaction ... See more keywords
Efficacy and Safety of Janus Kinase Inhibitors in Type I Interferon-Mediated Monogenic Autoinflammatory Disorders: A Scoping Review
Sign Up to like & getrecommendations! Published in 2021 at "Dermatology and Therapy"
DOI: 10.1007/s13555-021-00517-9
Abstract: Type I interferon (IFN)-mediated monogenic autoinflammatory disorders (interferonopathies) are childhood-onset rare multisystemic diseases with limited treatment options. The Janus kinase (JAK) inhibitors are promising potential therapeutic candidates for immune-mediated chronic inflammatory skin diseases. To review… read more here.
Keywords: type interferon; mediated monogenic; monogenic autoinflammatory; safety ... See more keywords
The systemic autoinflammatory disorders for dermatologists. Part 1: overview
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DOI: 10.1111/ced.14250
Abstract: The systemic autoinflammatory disorders (SAIDs) or periodic fever syndromes are disorders of innate immunity, which can be inherited or acquired. They are almost all very rare and easily overlooked; typically, patients will have seen multiple… read more here.
Keywords: dermatologists part; systemic autoinflammatory; autoinflammatory disorders; disorders dermatologists ... See more keywords
Central nervous system manifestations of monogenic autoinflammatory disorders and the neurotropic features of SARS-CoV-2: Drawing the parallels
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.931179
Abstract: Central nervous system (CNS) involvement in monogenic autoinflammatory disorders (AID) is increasingly recognized and can be life threatening. Therefore, a low threshold to consider CNS disease should be maintained in patients with systemic inflammation. Hyperinflammation… read more here.
Keywords: autoinflammatory disorders; central nervous; covid; monogenic autoinflammatory ... See more keywords