Control of mRNA decapping by autoinhibition
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky233
Abstract: Abstract 5′ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are well-studied, the role of abundant intrinsically disordered regions (IDRs) is… read more here.
Keywords: decapping autoinhibition; control; control mrna; mrna decapping ... See more keywords
Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.05.494868
Abstract: Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein… read more here.
Keywords: intermediate chain; distribution protein; nuclear distribution; autoinhibition ... See more keywords
Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin Va
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add4187
Abstract: As the prototype of unconventional myosin motor family, myosin Va (MyoVa) transport cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa adopts a closed and autoinhibited state, which can be relieved by… read more here.
Keywords: structure; autoinhibition activation; myova; autoinhibition ... See more keywords
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc4479
Abstract: Weakening autoinhibition of the kinase ZAP70 leads to overactive T cells and autoimmune disease. Stronger responses to weak ligands The protein tyrosine kinase ZAP70 links activated T cell antigen receptors (TCRs) to downstream signaling pathways.… read more here.
Keywords: responses weak; r360p mutation; zap70; cell ... See more keywords
Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00144
Abstract: The advent of cell-cell and cell-extracellular adhesion enabled cells to interact in a coherent manner, forming larger structures and giving rise to the development of tissues, organs and complex multicellular life forms. The development of… read more here.
Keywords: mediated adhesion; adhesion; integrin mediated; cell ... See more keywords