Oligomerization-mediated autoinhibition and cofactor binding of a plant NLR
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07668-7
Abstract: Nucleotide-binding leucine-rich repeat (NLR) proteins play a pivotal role in plant immunity by recognizing pathogen effectors1,2. Maintaining a balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity3,4. Unlike most NLRs,… read more here.
Keywords: plant; slnrc2; binding; autoinhibition ... See more keywords
Substrate binding and coupled mechanisms of Vps4p substrate recruitment and release from autoinhibition
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-08418-z
Abstract: The ESCRT pathway’s AAA+ ATPase, Vps4p, remodels ESCRT-III complexes to drive membrane fission. Here, we use peptide binding assays to further the understanding of substrate specificity and the mechanism of autoinhibition. Our results revealed unexpected sequence… read more here.
Keywords: autoinhibition; substrate binding; substrate; binding coupled ... See more keywords
Cancer-associated mutations in protein kinase C theta are loss-of-function
Sign Up to like & getrecommendations! Published in 2024 at "Biochemical Journal"
DOI: 10.1042/bcj20240148
Abstract: The Ca2+-independent, but diacylglycerol-regulated, novel protein kinase C (PKC) theta (θ) is highly expressed in hematopoietic cells where it participates in immune signaling and platelet function. Mounting evidence suggests that PKCθ may be involved in… read more here.
Keywords: cancer; autoinhibition; function; pkc ... See more keywords
Talin autoinhibition is required for normal hemostasis.
Sign Up to like & getrecommendations! Published in 2025 at "Platelets"
DOI: 10.1080/09537104.2025.2555197
Abstract: ABSTRACT The integrin family of extracellular matrix (ECM) adhesion receptors plays a central role in platelet function, including adhesion and aggregation. In resting platelets, integrins exist in a low-affinity state for their ligands, and are… read more here.
Keywords: talin; talin autoinhibition; role; autoinhibition ... See more keywords
Control of mRNA decapping by autoinhibition
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky233
Abstract: Abstract 5′ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are well-studied, the role of abundant intrinsically disordered regions (IDRs) is… read more here.
Keywords: decapping autoinhibition; control; control mrna; mrna decapping ... See more keywords
Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.05.494868
Abstract: Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein… read more here.
Keywords: intermediate chain; distribution protein; nuclear distribution; autoinhibition ... See more keywords
Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin Va
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add4187
Abstract: As the prototype of unconventional myosin motor family, myosin Va (MyoVa) transport cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa adopts a closed and autoinhibited state, which can be relieved by… read more here.
Keywords: structure; autoinhibition activation; myova; autoinhibition ... See more keywords
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc4479
Abstract: Weakening autoinhibition of the kinase ZAP70 leads to overactive T cells and autoimmune disease. Stronger responses to weak ligands The protein tyrosine kinase ZAP70 links activated T cell antigen receptors (TCRs) to downstream signaling pathways.… read more here.
Keywords: responses weak; r360p mutation; zap70; cell ... See more keywords
Abstract 5739: Small molecule modulation of autoinhibition to inhibit DNA binding of ERG and FLI1 - therapeutic for Ewing sarcoma, prostate cancer, and ALL
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5739
Abstract: Targeting transcription factor-DNA interactions presents substantial challenges due to the convex and highly positively charged surface on the DNA binding domains that mediate DNA binding. Such a surface is far from ideal for development of… read more here.
Keywords: cancer; family; autoinhibition; dna binding ... See more keywords
Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00144
Abstract: The advent of cell-cell and cell-extracellular adhesion enabled cells to interact in a coherent manner, forming larger structures and giving rise to the development of tissues, organs and complex multicellular life forms. The development of… read more here.
Keywords: mediated adhesion; adhesion; integrin mediated; cell ... See more keywords