The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis
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DOI: 10.1007/s00415-022-11063-5
Abstract: Autologous haematopoietic stem cell transplantation (aHSCT) is gaining traction as a valuable treatment option for patients affected by severe multiple sclerosis (MS), particularly the relapsing–remitting form. We describe the current literature in terms of clinical… read more here.
Keywords: stem cell; treatment; autologous haematopoietic; transplantation ... See more keywords
Autologous haematopoietic stem cell therapy for multiple sclerosis: a review for supportive care clinicians on behalf of the Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation
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DOI: 10.1097/spc.0000000000000466
Abstract: Purpose of review In this review, we summarize the recently published literature that demonstrates the efficacy and safety of autologous haematopoietic stem cell therapy (AHSCT) in multiple sclerosis (MS) and highlight the importance of supportive… read more here.
Keywords: care; therapy; review; supportive care ... See more keywords
Autologous haematopoietic stem cell transplantation versus low‐dose immunosuppression in secondary–progressive multiple sclerosis
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DOI: 10.1111/ene.15280
Abstract: Effectiveness of autologous haematopoietic stem cell transplantation (AHSCT) in relapsing–remitting multiple sclerosis (MS) is well known, but in secondary–progressive (SP)‐MS it is still controversial. Therefore, AHSCT activity was evaluated in SP‐MS using low‐dose immunosuppression with… read more here.
Keywords: haematopoietic stem; stem cell; secondary progressive; cell transplantation ... See more keywords
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis
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DOI: 10.1136/ard-2021-221925
Abstract: Objectives Myeloablative autologous haematopoietic stem cell transplant (HSCT) was recently demonstrated to provide significant benefit over cyclophosphamide (CYC) in the treatment of diffuse cutaneous systemic sclerosis (dcSSc) in the Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial.… read more here.
Keywords: cell; haematopoietic stem; myeloablative autologous; autologous hsct ... See more keywords
Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation
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DOI: 10.3389/fimmu.2021.782935
Abstract: Autologous haematopoietic stem cell transplantation (AHSCT) is a therapeutic option for haematological malignancies, such as non-Hodgkin’s lymphoma (NHL), and more recently, for autoimmune diseases, such as treatment-refractory multiple sclerosis (MS). The immunological mechanisms underlying remission… read more here.
Keywords: patients following; proinflammatory cytokines; post ahsct; suppression ... See more keywords