End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid-Liquid Extraction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01646
Abstract: Herein, we report an end-to-end process including synthesis, work-up, purification, and post-purification with minimal human intervention using Negishi coupling as a key transformation to increase Fsp3 in bioactive molecules. The main advantages of this protocol… read more here.
Keywords: end end; liquid liquid; liquid; end ... See more keywords
Sensitive and Specific Detection of SARS-CoV-2 Antibodies Using a High-Throughput, Fully Automated Liquid-Handling Robotic System
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DOI: 10.1177/2472630320950663
Abstract: As of July 22, 2020, more than 14.7 million infections of SARS-CoV-2, the virus responsible for Coronavirus Disease 2019 (COVID-19), have been confirmed globally. Serological assays are essential for community screening, assessing infection prevalence, aiding… read more here.
Keywords: detection; automated liquid; liquid handling; sars cov ... See more keywords
Automation of Spatial Transcriptomics library preparation to enable rapid and robust insights into spatial organization of tissues
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DOI: 10.1186/s12864-020-6631-z
Abstract: Background Interest in studying the spatial distribution of gene expression in tissues is rapidly increasing. Spatial Transcriptomics is a novel sequencing-based technology that generates high-throughput information on the distribution, heterogeneity and co-expression of cells in… read more here.
Keywords: spatial transcriptomics; automated liquid; agilent bravo; liquid handling ... See more keywords