MicroRNA-34a Suppresses Autophagy in Alveolar Type II Epithelial Cells in Acute Lung Injury by Inhibiting FoxO3 Expression
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0537-1
Abstract: Excessive autophagic activity of alveolar type II epithelial (AT-II) cells is one of the main causes of acute lung injury (ALI); however, the underlying molecular mechanism remains to be determined. The microRNAs (miRNAs) are involved… read more here.
Keywords: alveolar type; mir 34a; expression; autophagic activity ... See more keywords
Liver X receptor activation induces podocyte injury via inhibiting autophagic activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00737-1
Abstract: Podocyte injury plays a key role in the occurrence and development of kidney diseases. Decreased autophagic activity in podocyte is closely related to its injury and the occurrence of proteinuria. Liver X receptors (LXRs), as… read more here.
Keywords: activation; autophagic activity; injury; lxr activation ... See more keywords
Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac007
Abstract: CD133 is a transmembrane protein that mainly localizes to the plasma membrane in hematopoietic/neural stem cells and cancer stem cells. Although CD133 also localizes to the cytoplasm and is degraded through autophagy, the precise mechanisms… read more here.
Keywords: autophagic activity; cd133 endosomes; cd133; pericentrosomal cd133 ... See more keywords
α-KG Up-regulates Autophagic Activity in Peri-implant Environment and Enhances Dental Implant Osseointegration in Osteoporotic Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13784
Abstract: AIM The osseointegration of dental implants is impaired among patients with osteoporosis, leading to significantly higher failure rate. This study set out to investigate the potential effects of alpha-ketoglutarate (α-KG) on implant osseointegration in an… read more here.
Keywords: autophagic activity; osseointegration; dental implant; implant osseointegration ... See more keywords
Impaired Autophagic Activity Contributes to the Pathogenesis of Bronchopulmonary Dysplasia: Evidence from Murine and Baboon Models.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2019-0445oc
Abstract: RATIONALE The incidence of bronchopulmonary dysplasia (BPD) has been increasing due to improved survival of extremely low birth weight infants. The pathogenesis of BPD is incompletely understood and there is a shortage of effective treatments.… read more here.
Keywords: bronchopulmonary dysplasia; baboon; impaired autophagic; mice ... See more keywords
Sodium–Glucose Cotransporter 2 Inhibitors Work as a “Regulator” of Autophagic Activity in Overnutrition Diseases
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DOI: 10.3389/fphar.2021.761842
Abstract: Several large clinical trials have shown renal and cardioprotective effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors in diabetes patients, and the protective mechanisms need to be elucidated. There have been accumulating studies which report that… read more here.
Keywords: sglt2 inhibitors; sodium glucose; overnutrition diseases; autophagic activity ... See more keywords
Dysregulated autophagic activity induced in response to chronic intermittent hypoxia contributes to the pathogenesis of NAFLD
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.941706
Abstract: Chronic intermittent hypoxia (CIH) is a pathological characteristic of obstructive sleep apnea (OSA) that has been linked to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The specific link between CIH, autophagic activity, and NAFLD,… read more here.
Keywords: autophagic activity; chronic intermittent; cih; intermittent hypoxia ... See more keywords