Oxidative stress‐mediated autophagic cell death participates in the neurotoxic effect on SH‐SY5Y cells induced by excessive iodide
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22571
Abstract: Excessive iodide could induce intellectual damage in children, which has attracted broad attention. To investigate the neurotoxic effect of iodide and its mechanism, a human dopaminergic neuroblastoma cell line (SH‐SY5Y) was treated with different concentrations… read more here.
Keywords: excessive iodide; iodide; cell death; autophagic cell ... See more keywords
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23705
Abstract: The detection of high levels of microplastics in indoor and outdoor air has increased concerns regarding its toxic effects on the respiratory system. They are not easily degradable and can be deposited deep in the… read more here.
Keywords: cell death; autophagic cell; bronchial epithelial; epithelial cells ... See more keywords
Ochratoxin A causes mitochondrial dysfunction, apoptotic and autophagic cell death and also induces mitochondrial biogenesis in human gastric epithelium cells
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02433-6
Abstract: Ochratoxin A (OTA) is a common natural contaminant found in human and animal food worldwide. Our previous work has shown that OTA can cause oxidative DNA damage, G2 arrest and malignant transformation of human gastric… read more here.
Keywords: mitochondrial biogenesis; death also; cell death; autophagic cell ... See more keywords
Organoseleno cytostatic derivatives: Autophagic cell death with AMPK and JNK activation.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.074
Abstract: Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds were screened for their potency and selectivity… read more here.
Keywords: cytostatic derivatives; organoseleno cytostatic; cell death; autophagic cell ... See more keywords
Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.80
Abstract: Activating alternative cell death pathways, including autophagic cell death, is a promising direction to overcome the apoptosis resistance observed in various cancers. Yet, whether autophagy acts as a death mechanism by over consumption of intracellular… read more here.
Keywords: autophagic cell; signalome wide; death; cell death ... See more keywords
Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64880-x
Abstract: Vitamin K2 has been shown to exert remarkable anticancer activity. However, the detailed mechanism remains unclear. Here, our study was the first to show that Vitamin K2 significantly promoted the glycolysis in bladder cancer cells… read more here.
Keywords: bladder cancer; glycolysis; akt hif; pi3k akt ... See more keywords
Berberine Induces Autophagic Cell Death by Inactivating the Akt/mTOR Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Planta medica"
DOI: 10.1055/a-1752-0311
Abstract: The incidence of skin cancer has been increasing over the past decades, and melanoma is considered highly malignant because of its high rate of metastasis. Plant-derived berberine, an isoquinoline quaternary alkaloid, has been reported to… read more here.
Keywords: cell death; autophagic cell; cell; akt mtor ... See more keywords
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16412
Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light‐emitting diodes (LED)‐based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Here,… read more here.
Keywords: autophagic cell; blue led; beclin; led irradiation ... See more keywords
Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation
Sign Up to like & getrecommendations! Published in 2020 at "Particle and Fibre Toxicology"
DOI: 10.1186/s12989-020-00379-7
Abstract: Background With the development of zinc oxide nanoparticles (ZnO NPs) in the field of nanotechnology, their toxicological effects are attracting increasing attention, and the mechanisms for ZnO NPs neurotoxicity remain obscure. In an attempt to… read more here.
Keywords: zno nps; zinc; autophagic cell; cell death ... See more keywords
Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death
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DOI: 10.18632/oncotarget.15616
Abstract: Cancers illustrating resistance towards apoptosis is one of the main factors causing clinical failure of conventional chemotherapy. Innovative therapeutic methods which can overcome the non-apoptotic phenotype are needed. The AMP-activated protein kinase (AMPK) is the… read more here.
Keywords: autophagic cell; ampk activator; cancer cells; ampk ... See more keywords
PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20415
Abstract: The crosstalk between apoptosis and autophagy contributes to tumorigenesis and cancer therapy. The process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates apoptosis and autophagy as a cancer therapy is unclear. In this… read more here.
Keywords: autophagic cell; apoptosis autophagic; cell; cell death ... See more keywords