EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2772
Abstract: Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and correlates with poor prognosis. EGFR has been demonstrated to be associated with cancer stem cell traits in HNSCC.… read more here.
Keywords: egfr; oral cancer; autophagic degradation; cancer ... See more keywords
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2689
Abstract: When p62/Sequestosome‐1 binds to a ubiquitinated protein, it undergoes liquid–liquid phase separation (LLPS) and forms a membraneless organelle, p62 body. There are two major physiological functions of the p62 body. One is effective autophagic degradation… read more here.
Keywords: p62 body; degradation; phase separation; autophagic degradation ... See more keywords
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.09.019
Abstract: Silica dust mainly attacks alveolar macrophages (AMs). The apoptosis of AMs is correlated with the progress of silicosis. Our previous study showed that autophagic degradation was blocked in AMs from silicosis patients. However, the effects… read more here.
Keywords: apoptosis; nicotine induces; autophagic degradation; silicosis ... See more keywords
Isarubrolone C Promotes Autophagic Degradation of Virus Proteins via Activating ATG10S in HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01161
Abstract: Isarubrolone C is a bioactive polycyclic tropoloalkaloid from Streptomyces. Our previous study showed that isarubrolone C could trigger autophagy. Here, we report isarubrolone C potential in broad-spectrum antiviral effect and its antiviral mechanism in vitro.… read more here.
Keywords: autophagic degradation; viral proteins; proteins via; isarubrolone promotes ... See more keywords
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113454119
Abstract: Significance Histone methylation regulates gene transcription through a variety of methylases and demethylases. The regulatory role of autophagy, an important process of protein degradation and recycling, in these histone modifiers is still unclear. We report… read more here.
Keywords: inflammation; kdm4d; histone; autophagic degradation ... See more keywords
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1632104
Abstract: ABSTRACT Glucosamine (GlcN), a dietary supplement widely utilized to promote joint health and effective in the treatment of osteoarthritis, is an effective macroautophagy/autophagy activator in vitro and in vivo. Previous studies have shown that autophagy… read more here.
Keywords: hepatitis; hbv; autophagic degradation; glucosamine ... See more keywords
UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2076192
Abstract: ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activation of… read more here.
Keywords: autophagic degradation; sting1; cyclic gmp; sting1 signaling ... See more keywords
A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2116676
Abstract: ABSTRACT Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while viruses have developed multiple ways to evade the host autophagic degradation. However, little is known as to whether viruses can target lipids to subvert… read more here.
Keywords: autophagic degradation; degradation insect; phosphatidylinositol bisphosphate; insect vector ... See more keywords
Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14712
Abstract: Endoplasmic reticulum (ER) stress has been highlighted as one of the factors involved in axon/dendrite degeneration, which is an early event in Alzheimer's, Parkinson's diseases as well as in acute disorders such as ischemia and… read more here.
Keywords: endoplasmic reticulum; degradation stromal; autophagic degradation; reticulum stress ... See more keywords
Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β
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DOI: 10.1371/journal.pbio.3001619
Abstract: Skeletal muscle regeneration is essential for maintaining muscle function in injury and muscular disease. Myogenesis plays key roles in forming new myofibers during the process. Here, through bioinformatic screen for the potential regulators of myogenesis… read more here.
Keywords: autophagic degradation; muscle; regeneration mice; muscle regeneration ... See more keywords
Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.785345
Abstract: Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied in experimental models and clinical trials for cancer treatment because of its anti-cancer property. However, the… read more here.
Keywords: emt angiogenesis; autophagic degradation; linked met; angiogenesis ... See more keywords