Autophagic Pathways to Clear the Tau Aggregates in Alzheimer’s Disease
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DOI: 10.1007/s10571-020-00897-0
Abstract: Tau is a microtubule-associated protein with an intrinsically unstructured conformation. Tau is subjected to several pathological post-translational modifications (PTMs), leading to its loss of interaction with microtubules and accumulation as neurofibrillary tangles (NFTs) in neurons.… read more here.
Keywords: degradation; tau; pathways clear; tau aggregates ... See more keywords
Neuroprotective Role of Quercetin on Rotenone-Induced Toxicity in SH-SY5Y Cell Line Through Modulation of Apoptotic and Autophagic Pathways
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DOI: 10.1007/s11064-020-03061-8
Abstract: The detrimental impact on the food chain due to the overuse of rotenone is partly responsible for alpha-synuclein (α-syn) mediated neurotoxicity. It is hypothesized that rotenone overdose leads to cytosolic proteopathy resulting in modulation of… read more here.
Keywords: rotenone; autophagic pathways; quercetin; rotenone induced ... See more keywords
Interplay of pathogenic forms of human tau with different autophagic pathways
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DOI: 10.1111/acel.12692
Abstract: Loss of neuronal proteostasis, a common feature of the aging brain, is accelerated in neurodegenerative disorders, including different types of tauopathies. Aberrant turnover of tau, a microtubule‐stabilizing protein, contributes to its accumulation and subsequent toxicity… read more here.
Keywords: degradation; degradation tau; tau; pathogenic forms ... See more keywords
Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia
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DOI: 10.1155/2020/8796103
Abstract: Ki20227, a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), has been suggested to regulate microglia inflammatory function and neuronal synaptic plasticity. Triptolide (TP) pretreatment has neuroprotective effects through its anti-inflammatory and antiapoptotic features in… read more here.
Keywords: improve cerebral; stimulating factor; bdnf akt; colony stimulating ... See more keywords