MTOR-mediates hepatic lipid metabolism through an autophagic SNARE complex
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DOI: 10.1080/15548627.2022.2037853
Abstract: ABSTRACT The STX17-SNAP29-VAMP8 SNARE complex mediates autophagosome-lysosome fusion. Our recent study showed that MTOR directly phosphorylates VAMP8ʹs T48 residue in nutrient-rich conditions. Phosphorylated VAMP8 inhibits autophagosome-lysosome fusion by blocking STX17-SNAP29-VAMP8 SNARE complex formation. Our study… read more here.
Keywords: lysosome fusion; snare; autophagosome lysosome; lipid metabolism ... See more keywords