Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr10131d
Abstract: We herein report a new biological consequence from a unique interaction between nanoparticles of ferric-tannic complexes (Fe-TA NPs) and liver cancer cells (HepG2.2.15). The Fe-TA NPs were found to accumulate into the cells via specific… read more here.
Keywords: autophagic stress; stress; cell invasion; cancer cell ... See more keywords
Lipid-mediated impairment of axonal lysosome transport contributing to autophagic stress
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1938916
Abstract: ABSTRACT Efficient degradation of autophagic vacuoles (AVs) generated at axon terminals by mature lysosomes enriched in the cell body represents an exceptional challenge that neurons face in maintaining cellular homeostasis. Here, we discuss our recent… read more here.
Keywords: autophagic stress; lipid mediated; lysosome transport; mediated impairment ... See more keywords
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
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DOI: 10.7554/elife.21776
Abstract: Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying… read more here.
Keywords: retrograde transport; autophagic stress; alzheimer disease; stress ... See more keywords