Spatio-Temporal Autophagy Tracking with a Cell-Permeable, Water-Soluble, Peptide-Based, Autophagic Vesicle-Targeted Sensor.
Sign Up to like & getrecommendations! Published in 2021 at "ACS sensors"
DOI: 10.1021/acssensors.1c00191
Abstract: Autophagy is an essential cellular degradation process. Impaired autophagy has been linked to multiple disorders, including cancer and neurodegeneration. Tracking the autophagic flux in living cells will provide mechanistic insights into autophagy and will allow… read more here.
Keywords: cell permeable; water; autophagic vesicles; autophagy ... See more keywords
Local biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression
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DOI: 10.1080/15548627.2022.2061757
Abstract: ABSTRACT Neurons are highly polarized and functionally compartmentalized cells. Under basal conditions, the biogenesis of autophagic vesicles (AVs) was previously shown to take place in the axon tip. As the sequestration of autophagic cargo occurs… read more here.
Keywords: long term; synaptic depression; biogenesis autophagic; autophagic vesicles ... See more keywords
Lipid and protein content profiling of isolated native autophagic vesicles
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DOI: 10.15252/embr.202153065
Abstract: Autophagy is responsible for clearance of an extensive portfolio of cargoes, which are sequestered into vesicles, called autophagosomes, and are delivered to lysosomes for degradation. The pathway is highly dynamic and responsive to several stress… read more here.
Keywords: autophagic vesicles; lipid protein; content profiling; native autophagic ... See more keywords