CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages
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DOI: 10.3389/fcimb.2022.819554
Abstract: Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore,… read more here.
Keywords: cystic fibrosis; autophago lysosomes; acidification; bacterial clearance ... See more keywords