Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24143
Abstract: Optineurin (OPTN) is an autophagy receptor protein that has been implicated in glaucoma and amyotrophic lateral sclerosis. OPTN‐mediated autophagy is a complex process involving many autophagy‐regulating proteins. Autophagy plays a critical role in removing damaged… read more here.
Keywords: rab1a; autophagosome formation; formation neuroblastoma; interaction ... See more keywords
Autophagosome Formation: Cutting the Gordian Knot at the ER
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.03.015
Abstract: Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now… read more here.
Keywords: formation cutting; formation; cutting gordian; membrane ... See more keywords
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.03.018
Abstract: Autophagy involves engulfment of cytoplasmic contents by double-membraned autophagosomes, which ultimately fuse with lysosomes to enable degradation of their substrates. We recently proposed that the tubular-vesicular recycling endosome membranes were a core platform on which… read more here.
Keywords: autophagosome formation; recycling endosome; centronuclear myopathy; autophagy ... See more keywords
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.024
Abstract: Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by using de novo double-membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar/lysosomal degradation. The Atg1 kinase… read more here.
Keywords: formation; regulation autophagy; atg1 kinase; autophagosome formation ... See more keywords
Desialylation of Atg5 by sialidase (Neu2) enhances autophagosome formation to induce anchorage-dependent cell death in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-00391-y
Abstract: Increased sialylation is one of the hallmarks of ovarian cancer (OC) but its relation with programmed cell death is not known. Here we explored the molecular interplay between autophagy, apoptosis/anoikis, and aberrant-expression of the PI3K-Akt/mTOR… read more here.
Keywords: sialidase; cell; autophagosome formation; cell death ... See more keywords
Molecular regulation of autophagosome formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20210819
Abstract: Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders. The hallmark… read more here.
Keywords: autophagosome formation; molecular regulation; regulation autophagosome; formation ... See more keywords
Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1695401
Abstract: ABSTRACT Macroautophagy/autophagy is implicated in age-dependent neurodegenerative diseases, including amyotrophic lateral sclerosis and Parkinson, Huntington and Alzheimer diseases, suggesting that an age-related decline in neuronal autophagy may contribute to the onset of neurodegeneration. We identified… read more here.
Keywords: autophagy declines; age; declines substantially; autophagy ... See more keywords
VAMP724 and VAMP726 are involved in autophagosome formation in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2127240
Abstract: ABSTRACT Macroautophagy/autophagy, an evolutionarily conserved degradative process essential for cell homeostasis and development in eukaryotes, involves autophagosome formation and fusion with a lysosome/vacuole. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins play important roles… read more here.
Keywords: vamp724 vamp726; arabidopsis; microscopy; autophagosome formation ... See more keywords
Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13386
Abstract: Prevention of neointima formation is the key to improving long‐term outcomes after stenting or coronary artery bypass grafting. RNA N6‐methyladenosine (m6A) methylation has been reported to be involved in the development of various cardiovascular diseases,… read more here.
Keywords: phenotypic switching; autophagosome formation; formation; methyltransferase ... See more keywords
The sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00065.2019
Abstract: The Sympathetic Nervous System (SNS) activates cAMP signaling and promotes trophic effects on brown adipose tissue through poorly understood mechanisms. Because norepinephrine has been found to induce anti-proteolytic effects on muscle and heart, we hypothesized… read more here.
Keywords: system; ibat; adipose tissue; brown adipose ... See more keywords
Autophagosome formation in relation to the endoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-020-00691-6
Abstract: Autophagy is a process in which a myriad membrane structures called autophagosomes are formed de novo in a single cell, which deliver the engulfed substrates into lysosomes for degradation. The size of the autophagosomes is… read more here.
Keywords: endoplasmic reticulum; formation; autophagy; membrane ... See more keywords