β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.01.081
Abstract: Mutations in WDR45 and WDR45B cause the human neurological diseases β-propeller protein-associated neurodegeneration (BPAN) and intellectual disability (ID), respectively. WDR45 and WDR45B, along with WIPI1 and WIPI2, belong to a WD40 repeat-containing phosphatidylinositol-3-phosphate (PI(3)P)-binding protein… read more here.
Keywords: autophagosome maturation; proteins wdr45; wdr45 45b; wdr45 wdr45b ... See more keywords
Autophagosome maturation stymied by SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Cell"
DOI: 10.1016/j.devcel.2021.02.002
Abstract: Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex. read more here.
Keywords: sars cov; autophagosome maturation; stymied sars; maturation stymied ... See more keywords
Regulation of Syntaxin 17 during Autophagosome Maturation.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2018.10.003
Abstract: During macroautophagy, cytosolic elements are confined in autophagosomes before fusion with endolysosomes for degradation or recycling. Recruitment of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) factor syntaxin 17 (STX17) is instrumental for this maturation… read more here.
Keywords: maturation; autophagosome maturation; syntaxin autophagosome; regulation syntaxin ... See more keywords
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1760623
Abstract: ABSTRACT NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome initiation. In this study, we revealed an unknown… read more here.
Keywords: protein; autophagosome maturation; degradation; ccz1 ... See more keywords