p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.036
Abstract: Dynein-dynactin has an indispensable role in autophagy and p150glued is the largest component of the dynactin complex. Here, we characterized the effects of knockdown (KD) of endogenous p150glued and of the pathogenic mutation of p150glued… read more here.
Keywords: autophagosomes lysosomes; p150glued deficiency; periphery p150glued; fusion ... See more keywords
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2105562
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is the most common brain malignancy insensitive to radiotherapy (RT). Although macroautophagy/autophagy was reported to be a fundamental factor prolonging the survival of tumors under radiotherapeutic stress, the autophagic biomarkers coordinated… read more here.
Keywords: fusion autophagosomes; tgm2; autophagosomes lysosomes; gbm ... See more keywords
Diabetes influences the fusion of autophagosomes with lysosomes in SH-SY5Y cells and induces Aβ deposition and cognitive dysfunction in STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural Brain Research"
DOI: 10.2139/ssrn.4076981
Abstract: Diabetes has been regarded as an independent risk factor for Alzheimer's disease (AD). Our previous study found that diabetes activated autophagy, but lysosome function was impaired. Autophagy-lysosome dysfunction may be involved in Aβ deposition in… read more here.
Keywords: fusion; diabetic rats; fusion autophagosomes; induced diabetic ... See more keywords