Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13180
Abstract: Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise relationship between autophagy and cancer stemness requires further investigation. In this study, it was found that luminal and triple‐negative… read more here.
Keywords: mir 181a; triple negative; cancer stemness; cancer ... See more keywords
Inhibition of Pro‐Survival Autophagy Induced by Rare‐Earth Nanocomposites for Promoting Photothermal Therapy of Visualized Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202117
Abstract: Manipulation of autophagic processes has emerged as a promising strategy for synergizing nanoagent‐mediated photothermal therapy (PTT). Most of the current studies focus on improving PTT efficacy by inhibiting pro‐survival autophagy induced by the heat generated… read more here.
Keywords: survival autophagy; photothermal therapy; pro survival; autophagy ... See more keywords
Ghrelin ameliorates chronic obstructive pulmonary disease–associated infllammation and autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1933
Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and devastating condition characterized by poor airflow and breath. Smoking and other environmental factors–caused inflammations triggered excessive autophagy of normal lung epithelial cells, eventually leading to impaired… read more here.
Keywords: chronic obstructive; obstructive pulmonary; autophagy; pulmonary disease ... See more keywords
ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700054
Abstract: Activity‐dependent neuroprotective protein (ADNP), discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism‐like… read more here.
Keywords: schizophrenia; alzheimer disease; autism; adnp plays ... See more keywords
The strange case of Drp1 in autophagy: Jekyll and Hyde?
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DOI: 10.1002/bies.202100271
Abstract: There is a debate regarding the function of Drp1, a GTPase involved in mitochondrial fission, during the elimination of mitochondria by autophagy. A number of experiments indicate that Drp1 is needed to eliminate mitochondria during… read more here.
Keywords: drp1; autophagy jekyll; drp1 autophagy; strange case ... See more keywords
Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12332
Abstract: Autophagy is elevated in metastatic tumors and is often associated with active epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT is dependent on autophagy is largely unknown. This study aimed to identify the mechanisms… read more here.
Keywords: derived acetyl; autophagy derived; acetylation autophagy; autophagy ... See more keywords
Mesenchymal stem cells promote cell invasion and migration and autophagy‐induced epithelial‐mesenchymal transition in A549 lung adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3320
Abstract: Mesenchymal stem cells (MSCs) are recruited into the tumour microenvironment and promote tumour growth and metastasis. Tumour microenvironment‐induced autophagy is considered to suppress primary tumour formation by impairing migration and invasion. Whether these recruited MSCs… read more here.
Keywords: invasion; migration; autophagy; cell ... See more keywords
TSPAN8 alleviates high glucose‐induced apoptosis and autophagy via targeting mTORC2
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11870
Abstract: TSPAN8 mediates signal transduction from extracellular cues and regulates cell development, activation, growth, and motility. However, whether TSPAN8 is involved in the progression of diabetic nephropathy (DN) remains unclear. This study aimed to explore the… read more here.
Keywords: tspan8; apoptosis; apoptosis cells; high glucose ... See more keywords
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11874
Abstract: In previous studies, we found that dynorphin exerts antiepileptic effect by activating the kappa opioid receptor (KOR). However, the role of neuronal autophagy in dynorphin/KOR‐mediated antiepileptic is still unclear. This study aimed to investigate the… read more here.
Keywords: seizure; signaling pathway; mtor signaling; epilepsy ... See more keywords
Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32503
Abstract: Viruses can inhibit host autophagy through multiple mechanisms, and evasion of autophagy plays an important role in immune suppression and viral oncogenesis. Merkel cell polyomavirus (MCPyV) T‐antigens are expressed and involved in the pathogenesis of… read more here.
Keywords: cell polyomavirus; autophagy; merkel cell; mcpyv ... See more keywords
Suppressing ROS‐TFE3‐dependent autophagy enhances ivermectin‐induced apoptosis in human melanoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27490
Abstract: Melanoma is an aggressive skin malignancy with a high mortality rate; however, successful treatment remains a clinical challenge. Ivermectin, a broad‐spectrum antiparasitic drug, has recently been characterized as a potential anticancer agent due to its… read more here.
Keywords: apoptosis; ivermectin induced; autophagy; ivermectin ... See more keywords