SGK1, autophagy and cancer: an overview.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06836-6
Abstract: BACKGROUND The serum and glucocorticoid-induced kinase-1 (SGK1) belonging to the AGC protein kinase family phosphorylates serine and threonine residues of target proteins. It regulates numerous ion channels and transporters and promotes survival under cellular stress.… read more here.
Keywords: sgk1; autophagy cancer; biology; cancer ... See more keywords
Monitoring autophagy in cancer: from bench to bedside.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.05.016
Abstract: Autophagy refers to an essential mechanism that evolved to sustain eukaryotic homeostasis and metabolism during instances of nutrient deprivation. During autophagy, intracellular cargo is encapsulated and delivered to the lysosome for elimination. Loss of basal… read more here.
Keywords: cancer bench; autophagy cancer; monitoring autophagy; biology ... See more keywords
At a Glance: A History of Autophagy and Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.11.005
Abstract: Since the first discovery of the lysosome and the definition of autophagy by Christian de Duve more than 60 years ago, research on autophagy, a process targeting cytoplasmic materials for lysosomal degradation and recycling, has… read more here.
Keywords: autophagy cancer; autophagy; glance history; cancer ... See more keywords
Autophagy and cancer: basic mechanisms and inhibitor development.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15803
Abstract: Autophagy is a lysosomal degradation system of cytoplasmic components, and it contributes to cellular homeostasis through turnover of various biomolecules and organelles, often in a selective manner. Autophagy is closely related to cancer, but its… read more here.
Keywords: cancer basic; development; autophagy cancer; basic mechanisms ... See more keywords
The progression of HMGB1-induced autophagy in cancer biology
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s185876
Abstract: Autophagy is an important process of cellular degradation and has been proven to contribute to tumorigenesis. High-mobility group box 1 (HMGB1) is an abundant nonhistone protein that has been widely reported to play a central… read more here.
Keywords: biology; autophagy cancer; hmgb1; hmgb1 induced ... See more keywords
IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2017.00140
Abstract: Calcium ions (Ca2+) play a complex role in orchestrating diverse cellular processes, including cell death and survival. To trigger signaling cascades, intracellular Ca2+ is shuffled between the cytoplasm and the major Ca2+ stores, the endoplasmic… read more here.
Keywords: cancer; autophagy cancer; role autophagy; ca2 ... See more keywords
Modulation of Autophagy in Cancer Cells by Dietary Polyphenols
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10010123
Abstract: The role of autophagy is to degrade damaged or unnecessary cellular structures. Both in vivo and in vitro studies suggest a dual role of autophagy in cancer—it may promote the development of neoplasms, but it… read more here.
Keywords: autophagy cancer; modulation autophagy; autophagy; cancer cells ... See more keywords
Molecular Mechanisms of Autophagy in Cancer Development, Progression, and Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071596
Abstract: Autophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to… read more here.
Keywords: mechanisms autophagy; development; progression; autophagy cancer ... See more keywords
Small Molecule Inhibitors for Unc-51-like Autophagy-Activating Kinase Targeting Autophagy in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24020953
Abstract: Autophagy is a cellular process that removes damaged components of cells and recycles them as biochemical building blocks. Autophagy can also be induced to protect cells in response to intra- and extracellular stresses, including damage… read more here.
Keywords: unc like; autophagy cancer; like autophagy; autophagy activating ... See more keywords
Autophagy in Cancer Progression and Therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097973
Abstract: Autophagy is a catabolic process that is necessary for cellular homeostasis maintenance [...]. read more here.
Keywords: progression therapeutics; autophagy cancer; cancer progression;