Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
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DOI: 10.1080/15548627.2017.1405192
Abstract: ABSTRACT Macroautophagy/autophagy inhibition under stress conditions is often associated with increased cell death. We found that under nutrient limitation, activation of CASP8/caspase-8 was significantly increased in autophagy-deficient lung cancer cells, which precedes mitochondria outer membrane… read more here.
Keywords: apoptosis; casp8; autophagy; activation ... See more keywords