Synergistic Lysosomal Impairment and ER Stress Activation for Boosted Autophagy Dysfunction Based on Te Double-Headed Nano-Bullets.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201585
Abstract: To overcome the autophagy compromised mechanism of protective cellular processes by "eating"/"digesting" damaged organelles or potentially toxic materials with autolysosomes in tumor cells, lysosomal impairment can be utilized as a traditional autophagy dysfunction route for… read more here.
Keywords: lysosomal impairment; stress; dysfunction; tumor ... See more keywords
Comment on: “Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease”
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0533-5
Abstract: The paper by Fowler and Moussa [1] is an excellent review of potential new therapies for Parkinson’s disease. The review considers autophagy dysfunction in Parkinson’s disease and the important role of autophagy in dopaminergic neuron… read more here.
Keywords: dopaminergic neurons; autophagy dysfunction; disease; parkinson disease ... See more keywords
Enhanced Efficacy of Propranolol Therapy for Infantile Hemangiomas based on a Mesoporous Silica Nanoplatform through Mediating Autophagy Dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.02.033
Abstract: Infantile hemangioma is one of the most common vascular tumors, which might result in morbidity and mortality without timely intervention. Propranolol is currently the first-line therapy for hemangiomas, but its potential side effects and high… read more here.
Keywords: prn msn; autophagy dysfunction; mesoporous silica; propranolol ... See more keywords
Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of glaucoma"
DOI: 10.1097/ijg.0000000000000606
Abstract: In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from… read more here.
Keywords: autophagy dysfunction; glaucoma autophagy; exfoliation glaucoma; glaucoma ... See more keywords