Excessive fluoride impairs autophagy flux in ameloblasts which is prevented by the autophagy activator rapamycin
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23677
Abstract: Excessive fluoride intake can cause dental fluorosis during teeth development and growth. However, the mechanisms underlying fluoride‐induced enamel damage are still not fully elucidated. Previously, we observed fluoride‐induced autophagy in ameloblasts, but the effects of… read more here.
Keywords: excessive fluoride; fluoride; autophagy flux; expression ... See more keywords
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.061
Abstract: Hantavirus infection, which causes severe zoonotic diseases with high mortality in humans, has become a global public health concern. Here, we demonstrate that Hantaan virus (HTNV), the prevalent prototype of the hantavirus in Asia, can… read more here.
Keywords: immune responses; glycoprotein nucleocapsid; host; innate immune ... See more keywords
Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172616
Abstract: Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in 2-dimensional (2D) and 3-dimensional… read more here.
Keywords: myotoxicity; simvastatin induced; c2c12; simvastatin myotoxicity ... See more keywords
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.017
Abstract: mTORC1, the major homeostatic sensor and responder, regulates cell catabolism mainly by targeting autophagy. Here, we show that mTORC1 directly controls autophagosome formation via phosphorylation of WIPI2, a critical protein in isolation membrane growth and… read more here.
Keywords: degradation; huwe1; regulated huwe1; mtorc1 ... See more keywords
Copper(II) Complexes of Halogenated Quinoline Schiff Base Derivatives Enabled Cancer Therapy through Glutathione-Assisted Chemodynamic Therapy and Inhibition of Autophagy Flux.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00133
Abstract: Twelve new complexes Cu(L1)2-Cu(L12)2 were designed and synthesized to improve their chemotherapeutic properties. They showed considerable antiproliferative activity against T24 cancer cells but lower cytotoxicity to human normal cells HL-7702 and WI-38. A mechanism study… read more here.
Keywords: l10; autophagy flux; therapy; chemodynamic therapy ... See more keywords
A role of metallothionein-3 in radiation-induced autophagy in glioma cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58237-7
Abstract: Although metallothionein-3 ( MT3 ), a brain-enriched form of metallothioneins, has been linked to Alzheimer’s disease, little is known regarding the role of MT3 in glioma. As MT3 plays a role in autophagy in astrocytes,… read more here.
Keywords: zinc; glioma cells; role; autophagy flux ... See more keywords
Enhancement of autophagy flux by isopsoralen ameliorates interleukin-1β-stimulated apoptosis in rat chondrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2018.1537265
Abstract: Abstract Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the caspase-3 activity and… read more here.
Keywords: isopsoralen ameliorates; apoptosis; isopsoralen pretreatment; enhancement autophagy ... See more keywords
Aflatoxin B1 inhibited autophagy flux by inducing lysosomal alkalinization in HepG2 cells
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2021.1909196
Abstract: Abstract Aflatoxin B1 (AFB1) is a hazard food pollutant and the most toxic one of all the aflatoxins. It is mainly metabolized in the liver and exerts strong hepatotoxicity and carcinogenesis. Autophagy is an important… read more here.
Keywords: flux inducing; hepg2 cells; lysosomal alkalinization; autophagy flux ... See more keywords
NaSH increases SIRT1 activity and autophagy flux through sulfhydration to protect SH-SY5Y cells induced by MPP~+
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1804179
Abstract: ABSTRACT Parkinson’s disease (PD) is one of the most prevailing aging diseases around the world. The present study was to investigate the potential effect of hydrogen sulfide (H2S) and silent mating type information regulation 2… read more here.
Keywords: cells induced; induced mpp; sy5y cells; h2s ... See more keywords
P047 The ATG16L1 T300A polymorphism in Crohn’s Disease patients leads to abnormal autophagy flux in dendritic cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.176
Abstract: Crohn’s disease is a chronic inflammatory bowel disease, whose pathogenesis is largely determined by an inappropriate immune response towards luminal microbiota in genetically susceptible hosts, affecting in particular genes involved in the autophagy process. The… read more here.
Keywords: atg16l1 t300a; autophagy flux; dendritic cells; disease ... See more keywords
Ketamine Regulates the Autophagy Flux and Polarization of Microglia through the HMGB1-RAGE Axis and Exerts Antidepressant Effects in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac035
Abstract: Depression is a leading cause of disability worldwide. Here, we explored the role of the HMGB1-RAGE pathway in lipopolysaccharide (LPS)-induced depression-like behavior and microglial autophagy flux, neuroinflammation, and polarization in a mouse model. Male C57BL/6… read more here.
Keywords: autophagy flux; depression; hmgb1 rage; polarization ... See more keywords