Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07338-z
Abstract: Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas… read more here.
Keywords: degradation; autophagy gatekeeper; yap autophagy; liver ... See more keywords
Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
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DOI: 10.1080/15548627.2021.1935007
Abstract: ABSTRACT Different types of autophagy co-exist in all mammalian cells, however, the specific contribution of each of these autophagic pathways to the maintenance of cellular proteostasis and cellular function remains unknown. In this work, we… read more here.
Keywords: autophagy gatekeeper; mediated autophagy; chaperone mediated; proteostasis ... See more keywords