ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis
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DOI: 10.1136/gutjnl-2016-312485
Abstract: Objective Preoperative chemotherapy with irinotecan is associated with the development of steatohepatitis, which increases the risk of perioperative morbidity and mortality for liver surgery. The molecular mechanisms of this chemotherapeutic complication are widely unknown. Design… read more here.
Keywords: autophagy impairment; irinotecan induced; erk activation; steatohepatitis ... See more keywords
Impact of Autophagy Impairment on Experience- and Diet-Related Synaptic Plasticity
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DOI: 10.3390/ijms23169228
Abstract: The beneficial effects of diet and exercise on brain function are traditionally attributed to the enhancement of autophagy, which plays a key role in neuroprotection via the degradation of potentially harmful intracellular structures. The molecular… read more here.
Keywords: synaptic transmission; impact autophagy; plasticity; regulation ... See more keywords