Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Cell Biology"
DOI: 10.1038/s41556-024-01373-3
Abstract: β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45) gene encoding WIPI4 lead to… read more here.
Keywords: autophagy independent; ferroptosis; loss wipi4; neurodegeneration ... See more keywords
Unveiling the Noncanonical Autophagy-Independent Role of ATG7 and ATG9B in Head and Neck Squamous Cell Carcinoma (HNSCC)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/9253938
Abstract: The role of autophagy in cancer remains elusive, and nontargeted autophagy inhibitors have limited therapeutic effects in HNSCC. Here, we systematically analyzed the correlation of autophagy-related genes in HNSCC through TCGA and single-cell sequencing data… read more here.
Keywords: cell; noncanonical autophagy; role; autophagy independent ... See more keywords