Enzymatic Nanosphere‐to‐Nanofiber Transition and Autophagy Inducer Release Promote Tumor Chemotherapy
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DOI: 10.1002/adhm.202201916
Abstract: Chemotherapy has remained an effective and predominant cancer treatment for the past decades, but is hampered by its low response rate and severe systemic toxicity. Combination chemotherapies are proposed to address these issues, yet their… read more here.
Keywords: tumor; autophagy inducer; release; chemotherapy ... See more keywords
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Sign Up to like & getrecommendations! Published in 2020 at "Life Sciences"
DOI: 10.1016/j.lfs.2020.117662
Abstract: Abstract Aims Bronchopulmonary dysplasia (BPD) is a severe respiratory complication in preterm infants. This study reveals the molecular mechanism of autophagic agonists regulating the Nrf2-ARE pathway via p62 to improve alveolar development in BPD rats.… read more here.
Keywords: autophagy inducer; nrf2 pathway; bpd; bronchopulmonary dysplasia ... See more keywords
Autophagy inducer rapamycin treatment reduces IFN-I–mediated Inflammation and improves anti–HIV-1 T cell response in vivo
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DOI: 10.1172/jci.insight.159136
Abstract: A hallmark of HIV-1 infection is chronic inflammation, even in patients treated with antiretroviral therapy (ART). Chronic inflammation drives HIV-1 pathogenesis, leading to loss of CD4+ T cells and exhaustion of antiviral immunity. Therefore, strategies… read more here.
Keywords: reduces ifn; inflammation; cell; hiv ... See more keywords
Long Non-Coding RNA CKMT2-AS1 Reduces the Viability of Colorectal Cancer Cells by Targeting AKT/mTOR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v51i2.8685
Abstract: Background: Colorectal cancer (CRC) has not only seriously affected people’s lives, but also burdened the government healthcare system. Long non-coding RNAs (lncRNA) have attracted more and more attention in the cancer study field. Methods: Experiments… read more here.
Keywords: ckmt2 as1; autophagy inducer; colorectal cancer; cancer ... See more keywords
Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome
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DOI: 10.3389/fimmu.2018.01920
Abstract: The NLRP3 inflammasome is a multiprotein complex that plays a key role in the innate immune system, and aberrant activation of this complex is involved in the pathogenesis of inflammatory diseases. Carvedilol (CVL) is an… read more here.
Keywords: inducer inhibits; novel autophagy; cvl; inhibits nlrp3 ... See more keywords