Conjugation with Phenylalanine Enhances Autophagy-Inducing Activity of (-)-Epigallocatechin Gallate in Hepatic Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b05361
Abstract: Given the importance of (-)-epigallocatechin gallate (EGCG) as an autophagy-enhancing and thereby lipid-lowering agent, optimization of its activity warrants its therapeutic potential in the treatment of hepatic diseases as well as metabolic disorders. On the… read more here.
Keywords: epigallocatechin gallate; autophagy inducing; phenylalanine; inducing activity ... See more keywords
Autophagy-inducing natural compounds: a treasure resource for developing therapeutics against tissue fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2017.1279151
Abstract: Abstract Tissue fibrosis is a common pathologic change of many chronic diseases, which is characterized by extracellular matrix accumulation in tissues and dysfunction of the injured organs. Despite there recently gain mechanistic insight into the… read more here.
Keywords: natural compounds; therapeutics tissue; fibrosis; autophagy inducing ... See more keywords
Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.02015-17
Abstract: ABSTRACT Human cytomegalovirus (HCMV) is the top viral cause of birth defects worldwide, and current therapies have high toxicity. We previously reported that the mTOR-independent autophagy-inducing disaccharide trehalose inhibits HCMV replication in multiple cell types.… read more here.
Keywords: cell; treatment; human cytomegalovirus; autophagy inducing ... See more keywords
The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.618414
Abstract: The major causative agent of tuberculosis (TB), i.e., Mycobacterium tuberculosis (Mtb), has developed mechanisms to evade host defense responses and persist within host cells for prolonged periods of time. Mtb is also increasingly resistant to… read more here.
Keywords: mtb; autophagy inducing; tuberculosis; therapy ... See more keywords