Impairment of mitochondrial dynamics involved in iron oxide nanoparticle‐induced dysfunction of dendritic cells was alleviated by autophagy inhibitor 3‐methyladenine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3933
Abstract: Iron oxide nanoparticles are nanomaterials that are used extensively in the biomedical field, but they are associated with adverse effects, including mitochondrial toxicity. Mitochondrial homeostasis is achieved through dynamic stability based on two sets of… read more here.
Keywords: autophagy inhibitor; nanoparticle induced; iron oxide; dendritic cells ... See more keywords
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1511503
Abstract: ABSTRACT Currently, particular focus is placed on the implication of autophagy in a variety of human diseases, including cancer. Discovery of small-molecule modulators of autophagy as well as their potential use as anti-cancer therapeutic agents… read more here.
Keywords: autophagy inhibitor; late stage; lung cancer; non small ... See more keywords
Combination of the NRF2 Inhibitor and Autophagy Inhibitor Significantly Inhibited Tumorigenicity of Castration-Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/4182401
Abstract: Prostate cancer (PCa) is the most frequent cancer in men. Developing new treatment methods for CRPC will be a significant challenge in the clinical treatment of PCa. In conclusion, the results of this study show… read more here.
Keywords: inhibitor significantly; inhibitor; combination; autophagy inhibitor ... See more keywords
Combined Effects of Tanshinone IIA and an Autophagy Inhibitor on the Apoptosis of Leukemia Cells via p53, Apoptosis-Related Proteins and Oxidative Stress Pathways
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DOI: 10.1177/15347354221117776
Abstract: Background: Acute myeloid leukemia (AML) is a kind of hematopoietic malignancy with limited response and acquired resistance to therapy. Inducing apoptosis and inhibiting autophagy in tumor cells is a combinational strategy for the development of… read more here.
Keywords: autophagy inhibitor; leukemia cells; oxidative stress; apoptosis ... See more keywords
A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer
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DOI: 10.3390/cancers14143387
Abstract: Simple Summary Lung cancer is the main cause of cancer-related deaths worldwide, mainly due to treatment resistance. For that reason, it is necessary to develop novel therapeutic strategies to overcome this phenomenon. The aim of… read more here.
Keywords: lung cancer; late stage; autophagy inhibitor; cancer ... See more keywords
Identification of Anhydrodebromoaplysiatoxin as a Dichotomic Autophagy Inhibitor
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DOI: 10.3390/md21010046
Abstract: Dysfunctional autophagy is associated with various human diseases, e.g., cancer. The discovery of small molecules modulating autophagy with therapeutic potential could be significant. To this end, we screened the ability of a series of metabolites… read more here.
Keywords: autophagy inhibitor; identification anhydrodebromoaplysiatoxin; dichotomic autophagy; autophagy ... See more keywords
Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC
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DOI: 10.3390/toxins14050360
Abstract: The compound EACC (ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate) was recently reported to inhibit fusion of autophagosomes with lysosomes in a reversible manner by inhibiting recruitment of syntaxin 17 to autophagosomes. We report here that this compound… read more here.
Keywords: autophagy inhibitor; ricin; eacc; intoxication ... See more keywords